HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-methanesulfonylmethyl-3-nitro-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 1-methylsulfanylmethyl-3-nitro-1H-pyrazole | HCID 67190658 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-methanesulfonylmethyl-3-nitro-1H-pyrazole | HCID 67188965 | 80% |
Reaction Steps
Oxone (2.05 g, 3.36 mmol) was added to a mixture of 1-methylsulfanylmethyl-3-nitro-1H-pyrazole (194 mg, 1.12 mmol) in methanol (10 mL) and deionized water (100 μL) was allowed to proceed for 16 h with vigorous stirring. The solvent was removed in vacuo and the crude material was purified by ISCO flash column chromatography (Teledyne Isco RediSep Flash Column 10 g; 0% ethyl acetate/hexanes to 50% ethyl acetate/hexanes) afforded 1-methanesulfonylmethyl-3-nitro-1H-pyrazole as a white solid (184 mg, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935699B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-56903b4f1b0e46bcb31c03c0654946db |
| Source note | uspto-grants-2011_05 |