反应详情

1-Chloro-4-pyrrolidino-2-naphthol (2.47 g;0.010 mol), prepared as described in Example 6(a), was dissolved in 10% aqueous potassium hydroxide (50 ml) and was treated in the presence of palladium on charcoal (1.00 g;5%) at room temperature under 3 atmospheres of hydrogen until a stoichiometric amount of hydrogen was absorbed (approximately 24h). The palladium catalyst was removed by filtration and the filtrate neutralised with glacial acetic acid. The solution was extracted with dichloromethane (2×50 ml), the extracts combined, dried and evaporated to afford crude 4-pyrrolidino-2-naphthol as an unstable dark oil (0.58 g;27%). The crude product could not be purified further using conventional methods. ##STR28##

1. customwas absorbed (approximately 24h)
2. customThe palladium catalyst was removed by filtration
3. extractionThe solution was extracted with dichloromethane (2×50 ml)
4. customdried
5. customevaporated