2,6-Lutidine → HCID 86618046, compound

Participants

Reaction Conditions

Reaction Steps

3-{3-[2-(R)-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazol-1-ylmethyl}-benzoic acid (600 mg, 1.13 mmol) was suspended in methylene chloride (6 mL) and a 2.0 M solution of oxalyl chloride in methylene chloride (567 μL, 1.13 mmol) was added and the reaction stirred at 25° C. for 10 min. The solution was chilled to 0° C. and 2,6-lutidine (264 μL, 2.27 mmol) was added dropwise. The reaction continued to stir at 0° C. for 10 min to afford the crude 3-{3-[2-(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazol-1-ylmethyl}-benzoyl chloride as a 0.166 M solution in methylene chloride which was used in the following step with no further purification.

Provenance & Evidence