反应详情

In a Parr shaker bottle was placed 2-methyl-1-(3-nitro-pyrazol-1-yl)-propan-2-ol (prepared in example 74, 100 mg, 0.54 mmol), 10% palladium on activated carbon (10 mg) and ethanol (5 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 1 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentration in vacuo afforded l-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (78 mg, 94%) and taken on to the next step without characterization.

1. filtrationThe reaction was then filtered through a pad of celite
2. washwashed with ethanol and concentration in vacuo