HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → Tert-butyl 2-[(2-hydroxyethyl)amino]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl 2-[(2-hydroxyethyl)amino]acetate | HCID 11062917 | — |
Reaction Steps
The compound is prepared, in analogy with Example 1, from ethanolamine (18.33 g; 0.3 mol) and tert-butyl bromoacetate 58.6 g; 0.3 mol) in the presence of triethylamine (30.7 g; 0.3 mol) in anhydrous N,N-dimethylformamide (300 ml). The crude product is purified by chromatography on silica gel (eluent: chloroform/methanol, 16:1). Yield: 33.65 g (64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623049 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-0e3cdfb1f75f4415884ee63d02462007 |
| Source note | uspto-grants-1997_04 |