HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → N-Benzyloxycarbonyl-N-[2-(methanesulphonyloxy)ethyl]-glycine tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Tert-butyl 2-{[(benzyloxy)carbonyl](2-hydroxyethyl)amino}acetate | HCID 19959626 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-Benzyloxycarbonyl-N-[2-(methanesulphonyloxy)ethyl]-glycine tert-butyl ester | HCID 19959619 | — |
Reaction Steps
The product from Example 5 (14.4 g; 47 mmol) is reacted in anhydrous pyridine (270 ml) with methanesulphonyl chloride (4.47 ml; 58 mmol) and then worked up as described in Example 2. Yield: 14.7 g (82%), brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623049 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-759f8f5b90184a7bb32ee67fbd5b1723 |
| Source note | uspto-grants-1997_04 |