HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 2-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | N4-Benzoyl-1-tert-butyloxycarbonylmethylcytosine | HCID 22101730 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)acetic acid | HCID 15341978 | — |
Reaction Steps
The product from Example 18 is dissolved in trifluoroacetic acid (170 ml) and left at room temperature for 1 h 45 min. Subsequently, the mixture is codistilled five times with toluene and the product is dried in a desiccator over phosphorus pentoxide/potassium hydroxide for 24 h. Yield: 11.8 g (93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623049 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-3b4cb803a7ea41f7865db932c7cfa3d1 |
| Source note | uspto-grants-1997_04 |