Ethoxalyl chloride → HCID 14614597, compound

Temperature

0 °C

In a round bottom flask was placed methylene chloride (70 mL) and aluminum trichloride (6.09 g, 45.65 mmol) and it was cooled to 0° C. in an ice bath. To this was then added dropwise chloro-oxo-acetic acid ethyl ester (3.98 mL, 35.79 mmol) keeping the temperature of the solution below 5° C. and it was then stirred for 30 min at 0° C. After this time a solution of isopropylsulfanyl-benzene (5.00 g, 32.84 mmol) in methylene chloride (5 mL) was added dropwise while keeping the temperature of the solution below 5° C. The ice bath was then removed and the reaction allowed to warm up to 25° C. and stirred for 3 h. The reaction was then cooled back down to 0° C. in an ice bath and added dropwise ice water (20 mL) keeping the temperature of the solution below 20° C. It was then stirred for 15 min and then transferred to a separatory funnel and separated. The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) and then dried over magnesium sulfate, filtered and concentrated in vacuo to afford (4-isopropylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (5.85 g, 71%) as a yellow oil and used without further purification.

1. customIn a round bottom flask was placed
2. customthe temperature of the solution below 5° C. and it
3. customthe temperature of the solution below 5° C
4. customThe ice bath was then removed
5. temperatureto warm up to 25° C.
6. stirringstirred for 3 h
7. temperatureThe reaction was then cooled back down to 0° C. in an ice bath
8. additionadded dropwise ice water (20 mL)
9. customthe temperature of the solution below 20° C
10. stirringIt was then stirred for 15 min
11. customtransferred to a separatory funnel
12. customseparated
13. washThe organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL)
14. dry with materialdried over magnesium sulfate
15. filtrationfiltered
16. concentrationconcentrated in vacuo

ORD record

ord-745ce3c7896d4776aab8d1954a3b489e

Source dataset

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07935699B2