HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54626Generated: October 26, 2026
Methyl vinyl ketone → 2-Methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol
https://huagongshe.com/reaction/54626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol | HCID 54017886 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol | HCID 54232336 | — |
Reaction Steps
Dissolve 2-propyl-3-t-butyl-4-hydroxy-5-isopropylphenol (2.0 mol) and trimethyl orthoformate (0.3 L) in methanol (1.2 L) and degas. Place under a nitrogen atmosphere and cool to 3° C. and add concentrated sulfuric acid (5 mL). Add, by dropwise addition, methyl vinyl ketone (340 mL, 4.0 mol) and stir without cooling for 44 hours. Pour into aqueous sodium hydrogen carbonate and extract into ethyl ether. Dry (MgSO4) and evaporate the solvent in vacuo to give 2-methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05623052 |
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| Source dataset | uspto-grants-1997_04 |
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| ORD ID | ord-e3732344467b41fbb1deba342bfdf963 |
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| Source note | uspto-grants-1997_04 |
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