Potassium Carbonate → HCID 86602862, compound

Participants

Reaction Conditions

Reaction Steps

Thiophene-2-boronic acid (44 mg, 0.34 mmol), Pd(PPh3)4 (19 mg, 0.02 mmol), K2CO3 (71 mg, 0.51 mmol), and H2O (0.17 mL) were added to a solution of N-ethylcarbamate-5-methoxy-6-bromo-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole (from Example 30, Step A) (60 mg, 0.17 mmol) in dioxane (3 mL) and stirred overnight at 100° C. The reaction mixture was diluted with EtOAC and H2O, and filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was purified via a silica plug eluting with Hexanes/EtOAc (2/1, v/v). MS calculated for C20H25NO3S+H: 358, observed: 358.

Provenance & Evidence