反应详情

BBr3 (1.1 mL, 1.0 M in dichloromethane) was added to a solution of N-ethylcarbamate-5-methoxy-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole (from Example 2, step A) (0.31 g, 1.1 mmol) in CH2Cl2 (10 mL) at 0° C., and stirred overnight. The excess BBr3 was quenched with the dropwise addition of water (2 mL), and washed with saturated aqueous NaHCO3 (10 mL) and brine (10 mL). The organic extract was dried over MgSO4 and concentrated. The subtitle compound was obtained without further purification. MS calculated for C15H19NO3+H: 262, observed: 262.

1. customThe excess BBr3 was quenched with the dropwise addition of water (2 mL)
2. washwashed with saturated aqueous NaHCO3 (10 mL) and brine (10 mL)
3. extractionThe organic extract
4. dry with materialwas dried over MgSO4
5. concentrationconcentrated