HCID 57660189, compound → HCID 67198700, compound

HRID 546327Notes

Reaction equation

HRID 546327 reaction equation
[C:1]([O:5][C:6]([N:8]([CH3:22])[CH:9]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO>[C:1]([O:5][C:6]([N:8]([CH3:22])[C:9](=[CH:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 1

HCID 57660189HCID 57660189, compound

Product 1

HCID 67198700HCID 67198700, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(tert-Butoxycarbonyl-methyl-amino)-3-(3,4-dichloro-phenyl)-propionic acid, conversion 96%, ee 95% (HPLC, Chirobiotic R, 250 mm×4.6 mm, MeOH/0.1% TEA acetate pH 4.75 (40:60), 0.5 ml/min, ambient temperature, detection UV 230 nm, retention times 16.79 minutes and 21.53 minutes).

Sources & evidence

ORD record
ord-df167768e8a942549369c4420f4d514e
Source dataset
uspto-grants-2011_05
Patent number
US07935841B2

Reaction notes

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