HuagongsheHuagongshe Chemistry Print Report · For research reference only
TBAF tetrahydrofuran → 3'-o-Aminothymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | TBAF tetrahydrofuran | HCID 11078149 | — |
| Reactant | 3'-O-Amino-(t-butyldimethylsilyl)thymidine | HCID 69101893 | — |
| Product | 3'-o-Aminothymidine | HCID 190488 | 72% |
Reaction Steps
3'-O-Amino-(t-butyldimethylsilyl)thymidine was deblocked with (Bu)4NF/THF in standard way to furnish compound 4 (72%). Crystallized from ether/hexanes/ethanol as fine needles, mp 81° C. 1H NMR (Me2SO-d6) δ1.78 (s, 3, CH3), 2.17 and 2.45 (2m, 2, 2'CH2), 3.70 (m, 2, 5'CH2), 3.88 (m, 1, 4'H), 4.16 (m, 1, 3'H), 4.8 (br s, 1, 5'OH), 6.05 (dd, 1, 1'HM), 6.2 (br s, 2 NH2), 7.48 (s, 1, C6H), and 11.24 (br s, 1, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623070 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-b5ecf019055e48148398fb13f28e11ff |
| Source note | uspto-grants-1997_04 |