(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexane-1-carbaldehyde → 1-((2S,5R)-2-isopropyl-5-methylcyclohexyl)pentan-1-one

HRID 546378Notes

Reaction equation

HRID 546378 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([CH3:10])[CH2:6][C@H:5]1[CH:11]=[O:12])([CH3:3])[CH3:2].[CH2:13]([Mg]Br)[CH2:14][CH2:15][CH3:16]>>[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([CH3:10])[CH2:6][CH:5]1[C:11](=[O:12])[CH2:13][CH2:14][CH2:15][CH3:16])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 11252239(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexane-1-carbaldehydeHCID 178418682HCID 178418682, compound

Product 1

HCID 671908081-((2S,5R)-2-isopropyl-5-methylcyclohexyl)pentan-1-one

Procedure

The title compound was prepared following the general procedure of Example 1 starting from (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbaldehyde and butyl magnesium bromide.

Sources & evidence

ORD record
ord-9eee56e3ce40439ea96a7e6369eb2ad6
Source dataset
uspto-grants-2011_05
Patent number
US07935848B2

Reaction notes

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