Tetrabutylammonium Fluoride → HCID 58822274, compound

Participants

Reaction Steps

(1S,2S,4R)—N1-tert-Butoxycarbonyl-4-(tert-butyldiphenylsilyloxymethyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine (1.25 g) was dissolved in tetrahydrofuran (30 ml), and tetrabutylammonium fluoride (1 M solution, 2.5 ml), and the mixture was stirred at room temperature for 3 days. After the solvent was distilled off under reduced pressure, dichloromethane was added, and the reaction mixture was washed with water, the resultant organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography on silica gel (methanol:dichloromethane=1:20→1:10) to obtain the title compound (540 mg) as a pale yellow amorphous substance.

Provenance & Evidence