Methyl 7-chloroisoquinoline-3-carboxylate → 7-Chloroisoquinoline-3-carboxylic Acid Hydrochloride

Participants

Reaction Steps

Methyl 7-chloroisoquinoline-3-carboxylate (0.23 g) was dissolved in concentrated hydrochloric acid (10 ml) to heat the mixture for 18 hours under reflux. The temperature of the reaction mixture was dropped to room temperature, and deposits were collected by filtration and then washed with water to obtain the title compound (0.21 g) as a colorless solic.

Provenance & Evidence