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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 546529Generated: October 30, 2026

Hydrochloric Acid → HCID 68911497, compound

https://huagongshe.com/reaction/546529

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Fluoroindole-2-carboxylic acidHCID 1820—
ReactantHCID 58822229HCID 58822229—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68911497HCID 68911497—

Reaction Steps

(1S,2R,4R)—N1-tert-Butoxycarbonyl-4-methoxycarbonyl-N2-[(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with 5-fluoroindole-2-carboxylic acid in a similar manner to Example 118 to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935824B2
Source datasetuspto-grants-2011_05
ORD IDord-679860b09d824f238604249a75717b17
Source noteuspto-grants-2011_05