HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R)-3-(tert-butyldiphenylsilyloxy)pyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3R)-1-Benzyl-3-(tert-butyldiphenylsilyloxy)pyrrolidine | HCID 57432600 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Pd(II)-hydride | HCID 13628823 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3R)-3-(tert-butyldiphenylsilyloxy)pyrrolidine hydrochloride | HCID 66786051 | — |
Reaction Steps
(3R)-1-Benzyl-3-(tert-butyldiphenyl-silyloxy)pyrrolidine (1.18 g) was dissolved in methanol (12 ml), 1N hydrochloric acid (240 μl) and palladium hydride (221 mg) were added, and hydrogen was introduced to conduct catalytic reduction under normal pressure at room temperature for 4.5 hours. The catalyst was removed by filtration, and the filtrate was concentrated to solid under reduced pressure to obtain crude (3R)-3-(tert-butyldiphenyl-silyloxy)pyrrolidine hydrochloride (984 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935824B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-82fa1ca728e84f1d980b968f38f2a5a1 |
| Source note | uspto-grants-2011_05 |