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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 546546Generated: October 30, 2026

Hydrochloric Acid → HCID 67056812, compound

https://huagongshe.com/reaction/546546

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantLithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 23704331—
Reactanttert-Butyl [(1R,2S,5S)-2-[(6-chloroquinoline-2-carbonyl)amino]-5-(dimethylcarbamoyl)cyclohexyl]carbamateHCID 57416176—
SolventEthanolHCID 702—
ProductHCID 67056812HCID 67056812—

Reaction Steps

(1S,2R,4S)—N2-(tert-Butoxycarbonyl)-N1-[(6-chloroquinolin-2-yl)carbonyl]-4-(N,N-dimethyl-carbamoyl)-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935824B2
Source datasetuspto-grants-2011_05
ORD IDord-1eb9d923b12e4e24864bd8b7ceac099e
Source noteuspto-grants-2011_05