Cesium carbonate → HCID 23630298, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.45 g of 1-[(2-aminopyrimidin-4-yl)methyl]-3-(4-tert-butylphenyl)-5,5-dimethylimidazolidine-2,4-dione obtained in stage f) in 15 mL of dioxane are successively added under argon 0.29 g of 3-bromopyridine, 1.51 g of caesium carbonate, 0.085 g of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene and 0.027 g of palladium acetate. The reaction medium is heated at 120° C. for 5 hours. After cooling, the reaction mixture is filtered, and the filtrate is concentrated under reduced pressure. The residue obtained is purified by chromatography on a column of silica, eluting with dichloromethane, to give 76 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[2-(pyridin-3-ylamino)pyrimidin-4-ylmethyl]imidazolidine-2,4-dione, the characteristics of which are as follows:

Provenance & Evidence