Dimethylamine → HCID 23630299, compound

Participants

Reaction Steps

To a solution of 70 mg of phenyl (4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyrimidin-2-yl)carbamate obtained in stage a) below in 3 mL of tetrahydrofuran is introduced, under argon, 0.71 mL of a 2M solution of dimethylamine in tetrahydrofuran. After stirring for one hour at room temperature, the reaction medium is concentrated under reduced pressure and the residue is purified by chromatography on a column of silica, eluting with a dichloromethane/acetonitrile/methanol mixture (98/1/1 by volume) to give 20 mg of 3-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyrimidin-2-yl)-1,1-dimethylurea in the form of a white powder, the characteristics of which are as follows:

Provenance & Evidence