Acetic Anhydride → N-(2-Bromo-5-nitrophenyl)acetamide

HRID 546566Notes

Reaction equation

HRID 546566 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH:4][C:12](=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 826072-Bromo-5-nitroaniline

Product 1

HCID 21959509N-(2-Bromo-5-nitrophenyl)acetamide

Procedure

2.8 g of 2-bromo-5-nitroaniline are dissolved in 18 mL of acetic anhydride in a microwave oven reactor. After hermetically closing the reactor and reacting for one hour at 60° C. under microwave irradiation, the solid is filtered off and then washed with three times 10 mL of diethyl ether and dried to give 3 g of N-(2-bromo-5-nitrophenyl)acetamide in the form of a beige-coloured solid, the characteristics of which are as follows:

Workup

  1. customreacting for one hour at 60° C. under microwave irradiation
  2. filtrationthe solid is filtered off
  3. washwashed with three times 10 mL of diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-547ac2418c0b46c093955493b6672eb9
Source dataset
uspto-grants-2011_05
Patent number
US07935819B2

Reaction notes

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