反应详情

To a solution of 240 mg of N-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}-1-oxidopyridin-2-yl)acetamide obtained in stage a) below in 6 mL of ethanol are added 109 mg of sodium hydrogen carbonate and 75 mg of thiocarbonyl dichloride. After stirring for 2 hours 30 minutes, the solid in suspension is filtered off, washed with ethanol and dried. 220 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazol-idine-2,4-dione are obtained in the form of a beige-coloured powder, the characteristics of which are as follows:

1. filtrationthe solid in suspension is filtered off
2. washwashed with ethanol
3. customdried