N-Methylethylamine → HCID 67198477, compound

Participants

Reaction Steps

A solution of 100 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dione obtained in stage b) of Example 9 in 2 mL of dioxane and 24 μl of N-ethyl-N-methylamine is heated by microwave at 130° C. for 15 minutes. The reaction mixture is concentrated under reduced pressure and the residue is purified by chromatography on a column of silica, eluting with a mixture of petroleum ether and ethyl acetate (gradient 40/60 to 0/100 by volume) followed by HPLC (gradient: water/acetonitrile containing 0.1% formic acid) to give 12 mg of 3-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]methyl}pyridin-2-yl)-1-ethyl-1-methylurea, the characteristics of which are as follows:

Provenance & Evidence