N,N-Dimethyl-1,3-propanediamine → HCID 67201241, compound

Participants

Reaction Steps

A solution of 100 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dione obtained in stage b) of Example 9 in 2 mL of dioxane and 35 μl of N,N-dimethyl-1,3-propanediamine is heated by microwave at 130° C. for 15 minutes. The reaction mixture is concentrated under reduced pressure and the residue is purified by chromatography on a column of silica, eluting with a mixture of dichloromethane/methanol/aqueous ammonia (75/23/2 by volume) to give 72 mg of 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-[3-(dimethylamino)propyl]urea, the characteristics of which are as follows:

Provenance & Evidence