反应详情

温度

150 °C

A suspension of 0.6 g of 3-(4-tert-butylphenyl)-1-[(2-chloropyridin-4-yl)methyl]-5,5-dimethylimidazolidine-2,4-dione obtained in stage a) of Example 7 in 1.1 mL of cyclopropylamine is heated by microwave at 150° C. for 6 hours and then concentrated under reduced pressure. The residue is purified by chromatography on a column of silica, eluting with a mixture of petroleum ether and ethyl acetate (50/50 by volume) to give 48 mg of 3-(4-tert-butylphenyl)-1-{[2-(cyclopropylamino)pyridin-4-yl]methyl}-5,5-dimethylimidazolidine-2,4-dione, the characteristics of which are as follows:

1. concentrationconcentrated under reduced pressure
2. customThe residue is purified by chromatography on a column of silica
3. washeluting with a mixture of petroleum ether and ethyl acetate (50/50 by volume)