Hydrochloric Acid → 2-(4-{4,4-Dimethyl-2,5-dioxo-3-[2-(pyridin-3-ylamino)pyridin-4-ylmethyl]imidazolidin-1-yl}-phenyl)-2-methylpropionic acid

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Reaction Steps

To a solution of 0.34 g of methyl 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoate obtained in stage e) below in 20 mL of methanol, at room temperature, are added 7 mL of 1N potassium hydroxide. The reaction medium is heated at reflux for two hours and concentrated under reduced pressure. The residue obtained is taken up in 10 mL of water and then acidified with 2N HCl to pH=5. The white solid formed is filtered off and then dried to give 0.225 g of 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoic acid, the characteristics of which are as follows:

Provenance & Evidence