反应详情

To a solution of 5 g of 2-(4-nitrophenyl)-2-methylpropionic acid in 40 mL of methanol, under argon, are added 4 mL of sulphuric acid. The reaction medium is heated at reflux for 3 hours and concentrated under reduced pressure. The residue is taken up in a mixture of ice-water and dichloromethane, the phases are separated and the organic phase is dried over magnesium sulphate and filtered. The filtrate is concentrated under reduced pressure to give 5.18 g of methyl 2-methyl-2-(4-nitrophenyl)propanoate in the form of a pale yellow solid, the characteristics of which are as follows:

1. temperatureThe reaction medium is heated
2. temperatureat reflux for 3 hours
3. concentrationconcentrated under reduced pressure
4. additionThe residue is taken up in a mixture of ice-water and dichloromethane
5. customthe phases are separated
6. dry with materialthe organic phase is dried over magnesium sulphate
7. filtrationfiltered
8. concentrationThe filtrate is concentrated under reduced pressure