3-Aminopyridine → HCID 57626022, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 200 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dione obtained in stage b) of Example 9 in 4 mL of dioxane are added 53 mg of 3-aminopyridine. The reaction mixture is heated by microwave at 130° C. for 20 minutes and concentrated under reduced pressure. The residue is purified by chromatography on a column of silica, eluting with a mixture of dichloromethane and methanol (98/2 by volume) to give 129 mg of 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-pyridin-3-ylurea, the characteristics of which are as follows:

Provenance & Evidence