Ammonia → HCID 57625969, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 250 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dione obtained in stage b) of Example 9 in 5 mL of dioxane are added 6.5 mL of a 7N solution of ammonia in methanol. The reaction mixture is heated by microwave at 130° C. for 3 hours and concentrated under reduced pressure. The residue is purified by HPLC (gradient: water/acetonitrile containing 0.1% formic acid) to give 54 mg of 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]methyl}pyridin-2-yl)urea, the characteristics of which are as follows:

Provenance & Evidence