Cesium carbonate → HCID 57626014, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.872 g of 3-(4-tert-butylphenyl)-1-[(2-chloropyridin-4-yl)methyl]-5,5-dimethylimidazolidine-2,4-dione obtained in stage a) of Example 7 in 25 mL of dioxane are successively added, under argon, 430 mg of 4-aminopyridazine, 2.8 g of caesium carbonate, 156 mg of (9,9-dimethyl-9H-xanthene-3,6-diyl)bis(diphenylphosphine) [xantphos] and 50 mg of palladium diacetate. The reaction mixture is heated at 90° C. for 6 hours, filtered and concentrated under reduced pressure. The residue is purified by chromatography on a column of silica, eluting with a mixture of dichloromethane and methanol (98/2 by volume) to give 55 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-{[2-(pyridazin-4-ylamino)pyridin-4-yl]-methyl}imidazolidine-2,4-dione, the characteristics of which are as follows:

Provenance & Evidence