tert-Butyl carbazate → HCID 66839088, compound

Participants

Reaction Steps

IPEA (1.9 mL), HOBt (859 mg) and EDC (1.22 g) were added to a solution of 5-chloro-2-(3-fluorophenyl)pentanoic acid (734 mg) and tert-butyl carbazate (504 mg) in DMF (10 mL), and the reaction solution was stirred at room temperature for seven hours. Ethyl acetate and water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 711 mg of the title compound. The property values of the compound are as follows.

Provenance & Evidence