tert-Butyl carbazate → HCID 66839144, compound

Participants

Reaction Steps

IPEA (1.03 ml) and BOPCl (756 mg) were added to a solution of the crude 5-chloro-2-(tetrahydropyran-4-yl)valeric acid (442 mg) and tert-butyl carbazate (357 mg) in methylene chloride (7 ml), and the reaction solution was stirred at room temperature overnight. Ethyl acetate and water were added to the reaction solution, and the organic layer was separated. The organic layer was sequentially washed with 1 N hydrochloric acid, water, a saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The resulting residue was triturated with ethyl acetate to obtain 250 mg of the title compound. The property values of the compound are as follows.

Provenance & Evidence