HCID 66839038, compound → HCID 66839044, compound

HRID 546778Notes

Reaction equation

HRID 546778 reaction equation
C1(C)C=CC(S([CH2:9][CH2:10][C:11]2[N:29]=[C:14]3[CH:15]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:28])([F:27])[F:26])[CH2:16][CH2:17][CH2:18][N:13]3[N:12]=2)=O)=CC=1>C1(C)C=CC=CC=1>[F:28][C:25]([F:26])([F:27])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[CH:15]1[CH2:16][CH2:17][CH2:18][N:13]2[N:12]=[C:11]([CH:10]=[CH2:9])[N:29]=[C:14]12

Participants

3

Reactant 1

HCID 66839038HCID 66839038, compound

Product 1

HCID 66839044HCID 66839044, compoundYield 71.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-[2-(Toluene-4-sulfinyl)ethyl]-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine (8.87 g) was dissolved in toluene (300 ml), and the reaction solution was heated under reflux for three days. After leaving to cool, the reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (4.27 g). The property values of the compound are as follows.

Workup

  1. temperaturethe reaction solution was heated
  2. temperatureunder reflux for three days
  3. customAfter leaving
  4. temperatureto cool
  5. concentrationthe reaction solution was concentrated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-6c16a826b1e849cc9df26e60e541327b
Source dataset
uspto-grants-2011_05
Patent number
US07935815B2

Reaction notes

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