Oxygen → 2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-8-ol

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Reaction Steps

2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-Trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (50 mg) was dissolved in DMF (3 mL). Sodium hydride (containing 40% of mineral oil, 8.3 mg) was added and the reaction solution was stirred at room temperature for 10 minutes. The reaction solution was internally replaced with oxygen. The reaction solution was bubbled with oxygen and stirred for two hours. A sodium thiosulfate solution was added to the reaction solution, and the reaction solution was stirred at room temperature for 30 minutes. Ethyl acetate was added to the reaction solution and the organic layer was separated. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (carrier: Chromatorex Si; elution solvent: heptane:ethyl acetate=1:1→ethyl acetate→ethyl acetate:methanol=9:1) to obtain the title compound (10 mg). The property values of the compound are as follows.

Provenance & Evidence