Pyridine → HCID 57708953, compound

Participants

Reaction Steps

Trifluoromethanesulfonic anhydride (0.51 mL, 3.09 mmol) was added to a solution of 4-(1-{4-[3-(t-Butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenol (Example 3-(4); 1.18 g, 2.38 mmol) in dichloromethane (40 mL) and pyridine (0.35 mL, 4.28 mmol) at room temperature, and the mixture was stirred at the same temperature for 20 minutes. A saturated aqueous ammonium chloride solution, ethyl acetate and hexane were added to the mixture. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only to hexane/ethyl acetate=97/3) to give the title compound (11.31 g, 88%).

Provenance & Evidence