Tetrabutylammonium Fluoride → HCID 57709019, compound

Participants

Reaction Conditions

Reaction Steps

Tetra-n-butylammonium fluoride (1 M solution in tetrahydrofuran, 0.2 mL, 0.2 mmol) and tetrahydrofuran (1 mL) were added to 3-[4′-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2′-methyl-biphenyl-3-yl]-propionic acid methyl ester (Example 12-(2); 0.016 g, 0.025 mmol), and the mixture was stirred at 60° C. for four hours. A 30% sodium dihydrogenphosphate aqueous solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by preparative TLC (hexane/ethyl acetate=1/1) to give the title compound (0.012 g, 93%).

Provenance & Evidence