Hydrochloric Acid → [6-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic Acid

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Reaction Steps

A mixed solution of a 6 N sodium hydroxide aqueous solution (0.003 mL) with water (0.01 mL) was added to a solution of [6-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester (Example 23-(3); 1.7 mg, 0.0032 mmol) in methanol (0.07 mL) at room temperature, and the mixture was stirred at room temperature for four hours. The mixture was acidified with a hydrochloric acid aqueous solution, followed by extraction with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give the title compound (1.6 mg, 100%).

Provenance & Evidence