Chloromethyl Methyl Ether → HCID 57433076, compound

Participants

Reaction Steps

Potassium carbonate (1.8 g, 13.6 mmol) was added to a solution of 4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)-phenyl]-propyl}-2-methyl-phenol (Example 25-(1); 2.50 g, 5.45 mmol) in N,N-dimethylformamide (36 mL), and the mixture was stirred for 20 minutes. Then, methoxymethyl chloride (0.50 mL, 6.54 mmol) was added, and the mixture was stirred for one hour. A saturated aqueous ammonium chloride solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography (10% ethyl acetate/hexane) to give the title compound (1.46 g, 66%).

Provenance & Evidence