Tetrahydrofuran → HCID 57708956, compound

Participants

Reaction Steps

A 1.0 M solution of tetrabutylammonium fluoride in tetrahydrofuran (0.079 mL, 0.079 mmol) was added to [5-(4-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cyclopentylethynyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester (Example 94-(1); 38.2 mg, 0.0656 mmol), and the mixture was stirred for two hours. The reaction mixture was purified by silica gel chromatography (35 to 50% ethyl acetate/hexane) to give the title compound (13.1 mg, 39%).

Provenance & Evidence