Tetrabutylammonium Fluoride → HCID 57709027, compound

Participants

Reaction Steps

A 1.0 M solution of tetrabutylammonium fluoride in tetrahydrofuran (0.075 mL) was added to [5-(4-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cyclohexylethynyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester (Example 99-(1); 37.3 mg, 0.0625 mmol), and the mixture was stirred for two hours. The reaction mixture was purified by silica gel chromatography (45 to 50% ethyl acetate/hexane) to give the title compound (12.7 mg, 38%).

Provenance & Evidence