Potassium Phosphate, Tribasic → HCID 57709197, compound

Participants

Reaction Conditions

Reaction Steps

A solution of palladium acetate (3.4 mg, 0.0153 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (12.6 mg, 0.0307 mmol) and potassium phosphate (65.3 mg, 0.30 mmol) in water (0.050 mL) and toluene (0.250 mL) was stirred for three minutes. A solution of (4-chloro-2-fluoro-phenyl)acetic acid methyl ester (Example 40; 33.2 mg, 0.16 mmol) and 1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-ethyl]-cyclohexanol (Example 37-(2); 55.4 mg, 0.109 mmol) in toluene (0.150 mL) was added, and the mixture was stirred in a nitrogen atmosphere at 100° C. for three hours. After filtration through cotton plug, the filtrate was concentrated under reduced pressure. The residue was purified by thin layer silica gel chromatography (20% ethyl acetate/hexane) to give the title compound (45.6 mg, 76%).

Provenance & Evidence