Sodium Hydroxide → HCID 57709034, compound

Participants

Reaction Steps

A 1 N sodium hydroxide aqueous solution (0.180 mL, 0.180 mmol) was added to a solution of (E)-(4′-{1-ethyl-1-[4-(3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-3-fluoro-2′,6′-dimethyl-biphenyl-4-yl)acetic acid methyl ester (Example 118-(1); 32.5 mg, 0.060 mmol) in methanol-tetrahydrofuran (1:1, 4 mL), and the mixture was stirred at room temperature for 10 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution, followed by extraction with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to give the target compound as a colorless oil (23.8 mg, 75%).

Provenance & Evidence