Ammonium Chloride → HCID 67065139, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylformamide (2.0 mL) was added to 2-(4-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cycloheptylethynyl)-phenyl]-propyl}-2-methyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (Example 128-(2); 64.4 mg, 0.110 mmol), (4-bromo-phenyl)-acetic acid methyl ester (30.2 mg, 0.132 mmol), tetrakis(triphenylphosphine)palladium (0) (12.7 mg, 0.0110 mmol) and potassium phosphate (35.0 mg, 0.165 mmol), and the mixture was stirred with microwave heating at 140° C. for seven minutes in a nitrogen atmosphere. An ammonium chloride solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=100:0 to 85:15) to give the target compound as a colorless oil (27.0 mg, 46%).

Provenance & Evidence