反应详情

The bromide obtained in Step A is heated at reflux in 15 ml of acetic anhydride until completely dissolved. Cool and pour into 50 ml of cold water. Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time. Combine the organic phases, pass over a column of alumina and evaporate. Recrystallise the residue from ethyl acetate.

1. dissolutionuntil completely dissolved
2. temperatureCool
3. extractionNeutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time
4. customevaporate
5. customRecrystallise the residue from ethyl acetate