Sodium Hydroxide → HCID 57454148, compound

Participants

Reaction Steps

A 1 N sodium hydroxide aqueous solution (0.165 mL, 0.165 mmol) was added to a solution of {5-[4-(1-ethyl-1-{4-[(E)-2-(4-hydroxy-tetrahydro-pyran-4-yl)-vinyl]-3-methyl-phenyl}-propyl)-2-methyl-phenyl]-pyridin-3-yl}-acetic acid methyl ester (Example 133-(1); 29.1 mg, 0.055 mmol) in methanol-tetrahydrofuran (1:1, 2 mL), and the mixture was stirred at room temperature overnight. Then, the reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (ethyl acetate:methanol=10:4) to give the target compound as a colorless oil (15.7 mg, 56%).

Provenance & Evidence