Ammonium formate → HCID 57709157, compound

Participants

Reaction Conditions

Reaction Steps

Ammonium formate (100 mg, 1.6 mmol) and Pd/C (30 mg) were added to a solution of [5-(4-{1-ethyl-1-[4-(4-hydroxy-tetrahydrothiopyran-4-ylethynyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid (Example 137-(3); 5 mg, 0.01 mmol) in ethanol, and the mixture was stirred with microwave heating at 130° C. for 10 minutes. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by thin layer silica gel chromatography (dichloromethane/methanol=10/1) to give the title compound (3.5 mg, 70%).

Provenance & Evidence