反应详情

10% palladium carbon (13.0 mg) was added to a solution of [5-(4-{1-ethyl-1-[4-(1-hydroxy-cyclohexylethynyl)-3-methyl-phenyl]-propyl}-phenyl)-pyridin-3-yl]-acetic acid methyl ester (Example 147-(1); 29.7 mg, 0.058 mmol) in methanol (0.3 mL), and the mixture was stirred in a hydrogen atmosphere for 19 hours. The reaction solution was filtered and concentrated under reduced pressure to give the title compound (19.9 mg, 66%).

1. filtrationThe reaction solution was filtered
2. concentrationconcentrated under reduced pressure