反应详情

Acetic acid (58.8 ml, 933 mmol) and acetic anhydride (20.4 ml, 185 mmol) were added to cyclopropane-1,2,3-tricarboxylic acid (24.4 g, 140 mmol), followed by reacting the mixture while heating under reflux for 2 hours, concentrating the reaction solution into a half volume, filtering off deposited crystals, washing them with heptane and drying under reduced pressure, to obtain 2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid (18.1 g, 116 mmol, 83%).

1. temperaturewhile heating
2. temperatureunder reflux for 2 hours
3. concentrationconcentrating the reaction solution into a half volume
4. filtrationfiltering off
5. washwashing them with heptane
6. customdrying under reduced pressure