反应详情

A 0.5 N sodium hydroxide aqueous solution (0.064 mL) was added to a solution of (S)-amino-(4′-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2′-methyl-biphenyl-4-yl)acetic acid methyl ester (Example 166-(3); 12.0 mg, 0.0226 mmol) in methanol (0.50 mL) at room temperature, and the mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure to give the title compound (12.5 mg, 100%).

1. concentrationThe reaction mixture was concentrated under reduced pressure